Cushing's disease in cats is rare but it can occur, and when it does the symptoms can be alarming. Here, our Modesto vets share some of the symptoms of Cushing's disease in cats, and what causes this serious condition.

Cushing's Disease (Hyperadrenocorticism) in Cats

Hyperadrenocorticism, more commonly called Cushing's disease, is caused by the excessive and persistent production of cortisol from the adrenal glands. Excessive cortisol production can occur due to one of two underlying issues:

Iatrogenic Hyperadrenocorticism is a form of Cushing's disease that is caused by the long-term and high-dose use of cortisol-like drugs to treat allergies and inflammation caused by other health conditions, or progesterone-type drugs (progestagens) which are used to control reproductive cycling in female cats.
Naturally-Occurring Hyperadrenocorticism is characterized by excess cortisol production due to adrenal or pituitary gland tumors. Pituitary gland tumors can lead to the excessive production of adrenocorticotropic hormone, which can result in the adrenals becoming enlarged and producing excessive cortisol.

Signs of Cushing's Disease in Cats

Cushing's disease is quite rare in cats, however there are a number of symptoms that are characteristic of the condition. One of the most noticeable and troubling symptoms that can indicate your cat has Cushing's is extremely thin and fragile skin which breaks and bleeds with the slightest touch.

Diabetes generally occurs at the same time as Cushing's in cats, meaning symptoms of diabetes can point to Cushing's disease. Other symptoms of Cushing's in cats include:

Excessive thirst
Excessive urination
Swollen abdomen
Muscle wasting
Poor coat condition

Increased appetite
Lethargy
Weakness
Hair loss
Curling ear tips

If your cat is showing any of the symptoms above contact your vet to book an examination for your cat.

Treatment for Cats with Cushing's Disease

The treatment of Cushing's disease largely depends upon the underlying cause of the condition:

If your cat is diagnosed with iatrogenic hyperadrenocorticism your vet will prescribe a controlled and gradual withdrawal of the medications that are causing the disease. Alternative medications will need to be prescribed to treat the underlying condition for which the problematic drug was originally prescribed.

If your cat is suffering from naturally-occurring hyperadrenocorticism your vet may recommend one or more of the following treatments:

Drug therapy – While a number of different drugs have been used to suppress cortisol production, few of these have been proven effective in cats. Trilostane appears to work best in cats and is the most commonly prescribed. This medication is administered once or twice a day. Drug therapy may help to relieve your cat's Cushing's symptoms although it can take a fair amount of time to see results.
Surgical adrenalectomy – The surgical removal of an adrenal gland can be a good treatment option if just one adrenal gland is affected.
Hypophysectomy – The surgical removal of the pituitary gland is a challenging and potentially risky surgery that is typically only used in extreme cases.
Radiation for pituitary tumors – Availability of this treatment can be limited but often proves to be effective in treating cats with Cushing's disease.